skin science
The Importance of Bioavailability In Skin Care
The efficacy of your skin care is determined by both the concentration of active ingredients, and their bioavailability.
skin science
The Importance of Bioavailability In Skin Care
The efficacy of your skin care is determined by both the concentration of active ingredients, and their bioavailability.
In skin care, the efficacy of an ingredient is not only determined by its concentration, but by its bioavailability. Bioavailability refers to the proportion of an ingredient that effectively absorbs and becomes active at a cellular level—and this is where nature holds a remarkable advantage.
Whole botanical ingredients have evolved as biological systems—carrying vitamins, antioxidants, fatty acids, phytonutrients, and more within the same cellular architecture. Rather than existing as isolated compounds, botanicals suspend nutrients within lipid structures that mimic those found naturally in healthy skin. This biological compatibility promotes efficient absorption, allowing these nutrients to integrate within the skin’s own lipid matrix.
In contrast, once a nutrient is isolated from its natural source—which is the case with most synthetic ingredients—much of the biological framework that supports its stability, absorption, and function is lost. Modern formulation may compensate through stabilization and delivery technologies, but these innovations are ultimately designed to recreate what botanicals are inherently capable of.
Bioavailability is one of our leading formulation principles. Our focus is whole botanicals that preserve the naturally occurring lipids, phytonutrients, and cofactors that sustain nutrient stability and absorption. We favor wild-harvested ingredients, cold-pressed oils, and biomimetic lipids that work in harmony with your skin’s physiology, creating formulas that preserve barrier integrity while delivering active benefits.
The Ritual Serum represents this philosophy, as a concentrated blend of whole botanical oils and extracts that have been chosen for both their demonstrated efficacy and biological compatibility. Acerola, one of nature’s richest sources of Vitamin C, delivers far more nutrients than the synthetic isolate L-Ascorbic Acid. Within the whole fruit of an Acerola Cherry, Vitamin C exists alongside polyphenols, flavonoids, and numerous compounds that ensure its stability and biocompatibility. Other lipid-rich active botanicals—such as Rosehip and Sacha Inchi—enhance absorption while supporting skin barrier function.
The result is an active formulation that works with the physiology of the skin rather than against it. This has always been our directive: to preserve the intelligence of nature through advanced formulation, developing skin care that supports resilience, renewal, and longevity.
Fig 2.
LESSE RItual Serum.
LESSE Reading List: Bioavailability
02 Vitamin C: Natural vs. Synthetic