The Skin-Gut Connection, pt. I

We often treat skin concerns at the surface—but in truth, healthy skin is shaped by a constellation of internal and external factors. Toxic topical ingredients, stress levels, environmental exposure, and internal health all play a role in how our skin functions and regenerates. Among these, the gut microbiome is an area of increasing scientific focus in skin health.

The gut microbiome is a living ecosystem composed of trillions of bacteria and other microorganisms that supports everything from immune regulation to inflammation response. When out of balance, it can contribute to visible skin issues like breakouts or sensitivity. “About 70% of the immune system is in the gut,” explains Nicole McFall, founder of Well Public and a gut health advocate. “Because the immune and digestive systems are closely linked, gut health is central to reducing inflammation and preventing oxidative stress and disease.”

When the gut microbiome is imbalanced, it can set off a cascade of health issues, including persistent skin conditions like acne, eczema, and rosacea. But what causes this imbalance in the first place? Diets high in processed foods, refined sugars, industrial seed oils, and low in fiber can decrease microbial diversity and fuel the overgrowth of harmful bacteria. Environmental stressors such as chronic stress, poor sleep, antibiotic overuse, alcohol, and even certain skincare ingredients can also compromise the intestinal lining and microbiota. “Damage to the intestinal barrier or gut dysbiosis can trigger immune responses that show up on the skin as inflammation, redness, or breakouts,” McFall notes.

Several studies back this gut-skin connection. Research published in Frontiers in Microbiology shows that gut dysbiosis and increased intestinal permeability (known as "leaky gut") can lead to systemic inflammation that affects skin homeostasis. Over time, this inflammatory state can impair the skin's barrier function, making it more prone to acne, dryness, redness, or irritation. Nutrient deficiencies, particularly in zinc, omega-3 fatty acids, and antioxidants, also play a role, as they’re essential for both gut lining integrity and skin repair.

Repairing gut health begins with addressing the root causes. McFall emphasizes a plant-diverse, whole food diet rich in fiber and polyphenols, which feed beneficial gut bacteria and promote the production of short-chain fatty acids. These compounds can affect our skin flora and reduce inflammation throughout the body. Hydration, weekly movement, and stress regulation are equally essential. “The most effective and sustainable approach is one that combines nutrition, low-tox skincare, and consistent lifestyle practices,” she explains.

At LESSE, we believe skincare should support the whole system, not disrupt it. What we apply topically can support—or disrupt—internal health, including the gut. Each of our advanced formula are designed to be powerful in efficacy but gentle in application. Organic Aloe Vera, a natural prebiotic found in every formula from the Calming Cleanser to the Essential Moisturizer, nourishes beneficial bacteria. Jojoba, a biomimetic lipid, reinforces microbial harmony while protecting the skin’s natural lipid barrier. And bioactive extracts like Tremella Mushroom, Centella Asiatica, and Chamomile deliver potent anti-inflammatory and reparative properties—ideal for nurturing a thriving microbiome both on the skin and gut, systemically.

“What we put on our skin can potentially affect the whole system,” McFall reminds us. Thoughtful, natural skin care can be therapeutic—especially during detox or dietary shifts when the skin may purge before it clears. Whether you're navigating a chronic condition or simply supporting your body’s natural rhythms, building skin health from the inside out is a practice of both rigorous science and gentle self care.

Fig 2.
Images courtesy of Well Public

This is the first of a two-part series. Sign up for our newsletter to receive part II, an in-depth interview with Nicole McFall — a functional medicine practitioner, gut health advocate, and the founder of Well Public.

For further reading, explore our article on the Skin Microbiome.


Title Image. Courtesy of Well Public.